Recently Added Targets
- Dihydroorotate dehydrogenase (quinone), mitochondrial, Plasmodium falciparum (isolate Dd2), A0A0L7M6L3 (Curated 04/23/24), : 5 subμM ligands
- Dihydroorotate dehydrogenase (quinone), mitochondrial, malaria parasite P. vivax, A0A1G4H0K4 (Curated 04/23/24), : 13 subμM ligands
- Decaprenyl-phosphate N-acetylglucosaminephosphotransferase, Mycobacterium smegmatis, A0R211 (Curated 04/22/24), wecA: 1 subμM ligands
- L,D-transpeptidase 2, Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), I6Y9J2 (Curated 04/19/24), ldtB: 1 subμM ligands
- Serine/threonine-protein phosphatase 6 catalytic subunit, Human, O00743 (Curated 04/19/24), PPP6C: 3 subμM ligands
- Trypanothione synthetase, Crithidia fasciculata, O60993 (Curated 04/23/24), TRS: 1 subμM ligands
- Sphingomyelin phosphodiesterase 2, Mouse, O70572 (Curated 04/18/24), Smpd2: 2 subμM ligands
- Monocarboxylate transporter 3, Human, O95907 (Curated 04/19/24), SLC16A8: 1 subμM ligands
- Alpha-1-antichymotrypsin, Human, P01011 (Curated 04/22/24), SERPINA3: 1 subμM ligands
- Angiotensinogen, Human, P01019 (Curated 04/23/24), AGT: 4 subμM ligands
- Matrix protein 2, Influenza A virus (strain A/Puerto Rico/8/1934 H1N1), P06821 (Curated 04/22/24), M: 4 subμM ligands
- Corticoliberin, Human, P06850 (Curated 04/21/24), CRH: 1 subμM ligands
- tRNA (guanine-N(1)-)-methyltransferase, Escherichia coli (strain K12), P0A873 (Curated 04/22/24), trmD: 19 subμM ligands
- 23S rRNA methylase leader peptide, Escherichia coli, P10739 (Curated 04/22/24), ermC: 1 subμM ligands
- Myosin-1, Human, P12882 (Curated 03/04/24), MYH1: 6 subμM ligands
- Cytotoxic T-lymphocyte protein 4, Human, P16410 (Curated 04/22/24), CTLA4: 1 subμM ligands
- Proline--tRNA ligase, Escherichia coli (strain K12), P16659 (Curated 04/22/24), proS: 2 subμM ligands
- CTP synthase 1, Human, P17812 (Curated 04/20/24), CTPS1: 13 subμM ligands
- Sulfotransferase 1A1, Rat, P17988 (Curated 04/21/24), Sult1a1: 4 subμM ligands
- Thyrotropin receptor, Rat, P21463 (Curated 04/22/24), Tshr: 23 subμM ligands
- NAD-dependent malic enzyme, mitochondrial, Human, P23368 (Curated 04/18/24), ME2: 15 subμM ligands
- Ceramide synthase 1, Human, P27544 (Curated 04/18/24), CERS1: 1 subμM ligands
- Ceramide synthase 1, Mouse, P27545 (Curated 04/18/24), Cers1: 1 subμM ligands
- Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, Pig, P29804 (Curated 04/22/24), PDHA1: 3 subμM ligands
- Genome polyprotein, DENV-2, P29991 (Curated 04/04/24), : 7 subμM ligands
- Stefin-3, Mouse, P35173 (Curated 04/18/24), Stfa3: 5 subμM ligands
- Polycomb complex protein BMI-1, Human, P35226 (Curated 04/23/24), BMI1: 25 subμM ligands
- Albumin, Rabbit, P49065 (Curated 04/21/24), ALB: 2 subμM ligands
- Estrogen receptor, Bovine, P49884 (Curated 04/21/24), ESR1: 2 subμM ligands
- Monocarboxylate transporter 4, Mouse, P57787 (Curated 04/21/24), Slc16a3: 1 subμM ligands
- Transforming growth factor beta-2 proprotein, Human, P61812 (Curated 04/23/24), TGFB2: 4 subμM ligands
- CTP synthase 2, Mouse, P70303 (Curated 04/20/24), Ctps2: 3 subμM ligands
- CTP synthase 1, Mouse, P70698 (Curated 04/20/24), Ctps1: 4 subμM ligands
- E3 ubiquitin-protein ligase RNF4, Human, P78317 (Curated 04/18/24), RNF4: 1 subμM ligands
- O-phosphoserine sulfhydrylase, Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv), P9WP53 (Curated 04/23/24), cysM: 1 subμM ligands
- L-lactate dehydrogenase, malaria parasite P. falciparum, Q0PJ46 (Curated 04/20/24), LDH: 2 subμM ligands
- Interleukin-18, Human, Q14116 (Curated 04/19/24), IL18: 1 subμM ligands
- Peroxisomal acyl-coenzyme A oxidase 1, Human, Q15067 (Curated 04/22/24), ACOX1: 1 subμM ligands
- Mothers against decapentaplegic homolog 2, Human, Q15796 (Curated 04/22/24), SMAD2: 3 subμM ligands
- Diacylglycerol kinase delta, Human, Q16760 (Curated 04/12/24), DGKD: 119 subμM ligands
- NADP-dependent malic enzyme, mitochondrial, Human, Q16798 (Curated 04/18/24), ME3: 28 subμM ligands
- Lymphocyte antigen 6K, Human, Q17RY6 (Curated 04/18/24), LY6K: 1 subμM ligands
- Isopentenyl-diphosphate Delta-isomerase, Escherichia coli (strain K12), Q46822 (Curated 04/18/24), idi: 2 subμM ligands
- Somatostatin receptor type 2, Dog, Q49LX6 (Curated 04/18/24), SSTR2: 1 subμM ligands
- Hydroxysteroid 11-beta dehydrogenase 1, Rhesus macaque, Q56D22 (Curated 04/21/24), HSD11B1: 1 subμM ligands
- CTP synthase 2, Rat, Q5U2N0 (Curated 04/20/24), Ctps2: 4 subμM ligands
- Sphingolipid delta(4)-desaturase DES1, Rat, Q5XIF5 (Curated 04/18/24), Degs1: 1 subμM ligands
- Metabotropic glutamate receptor 7, Mouse, Q68ED2 (Curated 04/22/24), Grm7: 1 subμM ligands
- Proprotein convertase subtilisin/kexin type 9, Mouse, Q80W65 (Curated 04/20/24), Pcsk9: 2 subμM ligands
- Mannan-binding lectin serine protease 1, Rat, Q8CHN8 (Curated 03/04/24), Masp1: 21 subμM ligands
- Ribonuclease SLFN12, Human, Q8IYM2 (Curated 04/22/24), SLFN12: 1 subμM ligands
- NADPH oxidase organizer 1, Human, Q8NFA2 (Curated 04/22/24), NOXO1: 1 subμM ligands
- Delta and Notch-like epidermal growth factor-related receptor, Human, Q8NFT8 (Curated 04/18/24), DNER: 1 subμM ligands
- Fibroblast growth factor receptor substrate 2, Human, Q8WU20 (Curated 04/21/24), FRS2: 1 subμM ligands
- Kinesin-like protein KIF18A, Mouse, Q91WD7 (Curated 04/18/24), Kif18a: 1 subμM ligands
- Homeobox-leucine zipper protein PROTODERMAL FACTOR 2, Mouse-ear cress, Q93V99 (Curated 04/23/24), PDF2: 1 subμM ligands
- L-amino-acid oxidase, Human, Q96RQ9 (Curated 04/21/24), IL4I1: 14 subμM ligands
- AMP deaminase 2, Mouse, Q9DBT5 (Curated 04/20/24), Ampd2: 2 subμM ligands
- P2Y purinoceptor 6, Mouse, Q9ERK9 (Curated 04/19/24), P2ry6: 1 subμM ligands
- Cytochrome P450 4F11, Human, Q9HBI6 (Curated 04/20/24), CYP4F11: 2 subμM ligands
- Mannan-binding lectin serine protease 2, Rat, Q9JJS8 (Curated 03/04/24), Masp2: 20 subμM ligands
- Muscleblind-like protein 1, Human, Q9NR56 (Curated 04/18/24), MBNL1: 4 subμM ligands
- CTP synthase 2, Human, Q9NRF8 (Curated 04/20/24), CTPS2: 4 subμM ligands
- Interleukin-36 gamma, Human, Q9NZH8 (Curated 04/19/24), IL36G: 1 subμM ligands
- Protein fem-1 homolog B, Human, Q9UK73 (Curated 04/21/24), FEM1B: 1 subμM ligands
- Aminodeoxyfutalosine nucleosidase, Campylobacter pylori J99, Q9ZMY2 (Curated 04/21/24), mtnN: 3 subμM ligands
BindingDB Archive
BindingDB is archived quarterly at UC San Diego Library Digital Collections.
Coronavirus Binding Data
BindingDB has accelerated collection of COVID related data. You can find the result here.
Try the BindingDB Browser Extension
We are excited to share our new browser extension, BDBFind. Once installed in your browser, BDBFind automatically lets you know when BindingDB has the data from an article, PubMed Entry, or US Patent you are looking at online and provides direct links to view or download the data. Get BDBFind by searching for it in the Chrome webstore or in Firefox extensions or by following these links:
- https://chrome.google.com/webstore/search/bdbfind (Once installed, click on the "jigsaw puzzle" icon to keep the BDB icon displayed.)
- https://addons.mozilla.org/addon/bdbfind.
Watch BDBFind in action in this 1.5 minute video: To send feedback about BDBfind, please email us at bindingdb@gmail.com.
BindingDB Data Curation
BindingDB curates US Patents. We have scanned patents back to 2013 for suitable data and are currently up to date as of mid-2020. However, we cannot be sure of capturing all relevant patents, so if you know of a useful one we have missed, please let us know and we will try to curate it. As of April 27, 2024, BindingDB's patent dataset comprises:
- Patents: 7,070
- Binding measurements: 1,096,801
- Compounds: 531,075
- Target proteins: 2,663
- Assays: 10,152
- Average Number of Targets per Patent: 1.91
BindingDB curates a set of journals not covered by other public databases. As of April 27, 2024, the status of this curation effort is as follows:
- ACS Chemical Biology 2006-2017 (vol 1-12) data
- ACS BioChemistry 1965-2017 (vol 4-56) data
- Bioorganic Chemistry 1990-2017 (vol 18-73) data
- BMC Chemical Biology 2001-2010 (vol 1-10) data
- ChemBioChem 2001-2017 (vol 2-18) data
- Chemical Biology & Drug Design 2006-2017 (vol 67-89) data
- Chemistry & Biology 1995-2015 (vol 2-22) data
- Journal of Biological Chemistry 1982-2014 (vol 257-289) data
- Journal of Chemical Biology 2010-2010 (vol 3-3) data
- Journal of Enzyme Inhibition and Medicinal Chemistry 2002-2014 (vol 17-29) data
- Nature Chemical Biology 2005-2017 (vol 1-13) data
- Medicinal Chemistry Research 2004-2014 (vol 13-23) data
BindingDB is supported by NIH's National Institute of General Medical Sciences (R24GM144232), and is located at the Skaggs School of Pharmacy and Pharmaceutical Sciences of the University of California San Diego